A three phase disposable microextraction unit was constructed, in which a free liquid. Comparison of solid phase microextraction and hollow fiber liquid phase microextraction for the determination of pesticides in aqueous samples by gas chromatography triple quadrupole tandem mass spectrometry. A combination of hollow fiber liquid phase membrane extraction hflpme and lcmsms was used to simultaneously extract and detect the nsaids in fish. Hollow fiber liquid phase microextraction followed by high performance liquid chromatography for determination of ultratrace levels of seiv after derivatization in. Comparison of hollow fiber liquid phase microextraction and dispersive liquid liquid microextraction for the determination of organosulfur pesticides in environmental and beverage samples by gas chromatography with flame photometric detection. A simple and highly sensitive method that involves three phase hollow fiber supported liquid phase microextraction hflpme coupled with maltodextrin mdmodified capillary electrophoresis ce was successfully developed for the separation and determination of trace concentrations of citalopram cit enantiomers in urine samples. Dispersive liquid liquid microextraction, single drop microextraction, and hollow fiber lpme hflpme are different modes of lpme. The three main approaches to lpme are single drop microextraction sdme, hollow fiber liquid phase microextraction hflpme and dispersive liquid liquid microextraction dllme. Applications of these newly emerging developments in. The use of porous hollow fibers as the slm was a new approach combining the benefits of small volumes and high enrichment factors in sdme with the robustness and selectivity obtained with the slm technique. Threephase hollow fiber liquidphase microextraction and. Applications of liquidphase microextraction in the sample. It is also cheap as the fiber can be disposed once used, thus minimizing carry over problems. Psillakis, application of three phase hollow fiber liquidphase microextraction for the extraction of four parabens in water samples, 7th international conference on instrumental methods of analysis modern trends and applications ima 1822 september 2011.
Twophase hollow fiber liquidphase microextraction request pdf. For the first time, the surfactant free microemulsion reinforced hollow fiber liquid phase microextraction sfmehflpme was developed for the determination of phthalic acid esters paes followed by fieldenhanced sample injection with reverse migrating micelles fesirmm in capillary electrophoresis. Ligand assisted pseudostir bar hollow fiber solid liquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap water, and darongar river. For the first time, hollowfiber liquidphase microextraction combined with high performance liquid chromatographyultraviolet was used to. Pdf development of a new liquid phase microextraction. A hollow fibre liquid phase microextraction for gas chromatographic determination of some phydroxybenzoic acid esters has been developed. Liquidphase microextraction combined with hollow fiber as. The method employed lcmsms analysis and hollowfiber liquidphase microextraction hf lpme for sample preparation. Application of hollow fiber liquid phase microextraction for. Lpme is a technique for sample preparation that is extremely simple, affordable and virtually a solvent free. Pdf hollow fiber liquidphase microextraction hflpme offers an efficient. Highthroughput determination of nicotine in plasma by. Hollow uber based liquid phase microextraction hflpme followed by high performance liquid chromatography hplc coupled with ultraviolet uv detection was used for extraction of methylphenidate hydrochloride. Pdf developments in hollow fiber based liquidphase.
Liquid phase microextraction or solvent microextraction was developed as a fast, simple and inexpensive solventminimized liquid liquid extraction lle technique 8 9. Several innovative liquid phase microextraction lpme techniques that have emerged recently have also been applied as an aid in sample preparation of these samples. Applications of hollowfiber and related microextraction. Determination of conjugated estrogens in human urine using carriermediated hollow fiber liquid phase microextraction and lcmsms. Apr 25, 2002 two modes of liquid phase microextraction lpme combined with hollow fiber hf were developed for gas chromatographymass spectrometry gcms. The slm principle was applied to liquid phase microextraction for the first time by introducing hollow fiber liquid phase microextraction hflpme in 1999. Kinetic aspects of hollow fiber liquid phase microextraction and electromembrane extraction. For the first time, hollowfiber liquidphase microextraction combined with highperformance liquid chromatographyultraviolet was used to extract trans,transmuconic acid, in urine samples of workers who had been exposed to benzene. Pdf application of hollowfiberassisted liquidphase.
The organic membrane solventconsists of 1octanol immobilized in the pores of a hollow fiber. Hollow fiberliquid phase microextraction method based on. Qi decoction and the single herb, fructus aurantii immaturus, cortex magnoliae. A new hollow fiber liquidsolid phase microextraction. Sdme in its original form, first described by jeannot and cantwell in 1996 24, is the simplest way to perform lpme.
Vortexassisted hollowfiber liquidphase microextraction. Surfactantfree microemulsion reinforced hollowfiber liquid. Hollow fiber liquidphase microextraction hflpme technique was suggested to overcome some drawbacks of sdme, such as instability of microdrop and unsuitability of. Injection port derivatization following ionpair hollow. Pdf applications of liquidphase microextraction in the. Into of lumen of 30 mm of accurel membrane 3001200 pp membrana gmbh wuppertalgermany was put a 10 mm metallic piece, functionalizing the hollow fiber as a solvent bar and was used for. Eme involves the use of a small supported liquid membrane slm sustained in the wall of a porous hollow fiber.
The parameters affecting the metabolite extraction were optimized as follows. Hollow fiber supported liquidphase microextraction. Development of a new liquid phase microextraction method. Recently, hollow fiber liquid phase micro extraction hflpme, based on the application of a supported liquid membrane, was. For hflpme 1heptanol, 2octanone and dibutylether were studied as extracting solvents.
Hollow fiberbased liquid phase microextraction combined with. The sampling device was prepared by impregnating 1. Hollow fiber liquidphase microextraction hflpme is commonly used to minimize consumption of organic solvent for extraction and to protect the extraction phase from contamination or depletion 110. The factors affecting the metabolites extraction were optimized as follows. Features include high selectivity, good enrichment factors, and improved possibilities for automation. Hollow fiber liquid phase microextraction hflpme is commonly used to minimize consumption of organic solvent for extraction and to protect the extraction phase from contamination or depletion 110. Two modes of liquid phase microextraction lpme combined with hollow fiber hf were developed for gas chromatographymass spectrometry gcms. Journal of chromatography b 2009, 877 1819, 17581764. Hidalgo, evaluation of a tertiary system peracetic aciduv radiation for the removal of selected. The extracted chlorophenols were then separated, identified, and quantified by. Hollow fibre liquid phase microextraction of parabens. Membranes free fulltext hollow fiber supported liquid.
In this paper, a three phase hollow fiber based liquid phase microextraction hflpme combined with a hplc procedure using diode array dad and fluorescence detection fld has been developed for the determination of eight widely used fluoroquinolones. Dec 22, 2016 a novel application of three phase hollow fiber based liquid phase microextraction hflpme for the hplc determination of two endocrine disrupting compounds edcs, noctylphenol and n. To decrease the amount of manual work, promising steps toward automation. In this research, a novel efficient analytical method for determination of alkylpyrazines aps in some food samples was developed based on headspace hollow fiber protected liquid phase microextraction hshflpme method. Both methods allow the direct transfer of extracted analytes to a gcms system for analysis. Application of hollow fiber assisted liquidphase microextraction to identify avermectins in stream water using msms. Liquidphase microextraction an overview sciencedirect. Molecules free fulltext applications of liquidphase. A solid phase microextraction sorbent composite was developed using the solgel technique. Hollow fiber headspace liquidphase microextraction hfhslpme. Hollow fiberbased liquid phase microextraction followed by. It starts with an introduction to the method and its subclasses and further develops into three distinct sections of single.
For water, the average enrichment factor was increased to 3700 times. Direct hollow fiber liquid phase membrane extraction and lc. Determination of conjugated estrogens in human urine using. Pdf hollow fiber liquid phase microextraction followed. Extraction of cuii ions in wastewaters using new solid. Applications of these newly emerging developments in extraction and preconcentration of a vast category of compounds including heavy metals, pesticides, pharmaceuticals and abused drugs in complex matrices environmental and. The applicability of hollow fiber liquid phase microextraction hflpme combined with highperformance liquid chromatographyultraviolet detection hplcuv was evaluated for the extraction and determination of tamoxifen tam in biological fluids including human urine and plasma. Hollow fiber liquidphase microextraction request pdf. Different factors that can affect the extraction process such as extraction solvent, acceptor and donor phase composition, salt addition, stirring rate, extraction. Development of a new liquid phase microextraction method with. Hollow fiber liquidphase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and preconcentration. Ligand assisted pseudostir bar hollow fiber solidliquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap water, and darongar river water samples.
This work describes a new extraction method with hollowfiber liquidphase microextraction based on facilitated ph gradient transport for analyzing hippuric acid and mandelic acid in aqueous samples. Surfactantfree microemulsion reinforced hollowfiber. Electromembrane extraction, or eme, is a miniaturized liquid liquid extraction technique developed for sample preparation of aqueous samples prior to analysis by chromatography, electrophoresis, mass spectrometry, and related techniques in analytical chemistry. A novel application of three phase hollow fiber based liquid. Analysis of pbdes in soil, dust, spiked lake water, and. Hollow fiberprotected liquidphase microextraction of. Development of hollowfiber liquidphase microextraction. Hollow fiber liquid phase microextraction followed by high performance liquid chromatography for determination of ultratrace levels of seiv after derivatization in urine, plasma and natural water samples. Several innovative techniques of liquidphase microextraction lpme were invented. Liquidphase microextraction an overview sciencedirect topics. Sequential hollow fiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride antidiabetic drugs in biological fluids. Jan 15, 2009 read miniaturized hollow fiber assisted liquidphase microextraction and gas chromatographymass spectrometry for determination of benzophenone and derivates in human urine sample, journal of chromatography b on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The multiwalled carbon nanotubes mwcnts were added to a nanocomposite and the homogeneous, doped composite was injected into a polypropylene hollow fiber.
Pdf capillary electrophoresis and hollow fiber liquid. Chlorobenzene containing tetradecane as internal standard. Liquid phase microextraction lpme enables analytes to be extracted with a few microliters of an organic solvent. A new hollow fiber liquidsolid phase microextraction using. Hollow fiber liquid phase microextraction hflpme exhibits many advantages compared to the other microextraction techniques in terms of simplicity and minimum consumption of organic solvents. A method termed hollow fiber liquid phase microextraction hflpme was utilized to extract three chlo rophenols, 2chlorophenol 2cp, 2,4dichlorophenol 2,4dcp and 2,4,6trichlorophenol 2,4,6tcp, separately from water. Comparison of hollow fiber liquid phase microextraction. For this reason a twophase hollow fiber liquid phase microextraction method for the. Development of hollowfiber liquidphase microextraction method. Both methodologies, that is, static lpme with hf and dynamic lpme with hf, involved the use of a small volume of organic solvent impregnated in the hollow fiber, which was held by the needle of a conventional gc syringe. A novel method for the analysis of four polybrominated diphenyl ethers pbdes in environmental and human serum samples based on hollow fiber liquid phase microextraction hflpme followed by gas chromatographyinductively coupled plasma mass spectrometric gcicpms detection has been developed. A novel application of three phase hollow fiber based. Pdf application of hollow fiber liquid phase microextraction and. Hplpme relies on the extraction of target analytes from aqueous samples into a supported liquid membrane slm sustained in the pores of.
For the freezedried fish tissue, this new analytical method showed an average enrichment factor of 3000 times. Different steps of dispersive liquidliquid phase microextraction. Nov 20, 20 a new procedure is presented for the determination of low concentrations of lead and cadmium in water samples. Hollow fiber based liquid phase microextraction technique hflpme was proposed in 1999 as an efficient alternative to the conventional sample preparation methods. A homemade hollow fiberprotected headspace liquid phase microextraction was used for simultaneous derivatization and extraction of free cyanide in human. For the analysis of polar or ionizable analytes, a three phase system is frequently used with an organic solvent immobilized in the hollow fiber.
Hplpme relies on the extraction of target analytes from aqueous samples into a supported liquid membrane. Review article focused on hollow fiber liquidphase microextraction and. The enhancement technique involved dispersing al 2 o 3 particles in nbutanol to fill the pores and lumen of a polyether sulfone membrane fiber. Trace determination of tamoxifen in biological fluids using. The chapter comprises a short discussion of the basic setup and. Herein, to cope up with the demand for a simple, low cost, and more effective extracting strategy, we described and compared both conventional hollow fiber liquidphase microextraction hflpme and hfslpme techniques through a novel selfassembly stirring and microextraction integrated device, which was introduced by eshaghi et al. Request pdf hollow fiber liquidphase microextraction this chapter discusses hollow fiber liquidphase microextraction lpme. Hollow fiber based liquid phase microextraction with high. A new analytical method for the simultaneous determination of the antidiabetic drugs rosiglitazone ros and metformin hydrochloride mh with marked. This study involved the development, validation and application of a three phase hollow fiber liquid phase microextraction hflpme and liquid chromatography with diode array detection lcdad method for the simultaneous determination of the proton pump inhibitor ppi drugs omeprazole, pantoprazole and lansoprazole in human plasma. Both methodologies, that is, static lpme with hf and dynamic lpme with hf, involved the use of a small volume of organic solvent impregnated in the hollow fiber, which was held by the needle of a. Hollow fiberbased liquid phase microextraction hflpme. A novel liquid phase microextraction lpme method has been developed, by coating with hollow fiber a metallic paper pin. Efficiency of hollow fiber liquidphase microextraction.
Tamsulosin is used for the treatment of difficult urination, a common symptom of an enlarged prostate. For the first time, hollow fiber liquid phase microextraction combined with highperformance liquid chromatographyultraviolet was used to extract trans, transmuconic acid, in urine samples of workers who had been exposed to benzene. It can provide a high degree of selectivity and enrichment by eliminating carryover between single runs. Carbon nanotube assisted solgel based hollow fiber. Development of negligible depletion hollow fiberprotected. Hollowfiber solidphase microextraction hf spme, in spite of using a. A new hollow fiberliquidsolid phase microextraction for extraction of ginsenosides from a chinese compound formula was established using al 2 o 3 nanoparticles as the adsorbent. After hf lpme optimization the following condition was established. Among these methods, hflpme has inherent advantages over to the other methods due to use of porous hf which reduces or eliminates the problems originated from matrix of the samples. In highthroughput ultrasonication enhanced hollow fiber liquid phase microextraction huhflpme, ultrasonication was introduced into hflpme to enhance the mass transfer rate of the analytes in the two immiscible liquid phases, which resulted in a very short time for extraction equilibrium and a highthroughput analysis. In this study, a vortexassisted three phase hollow fiber liquid phase microextraction vahflpme coupling with high performance liquid chromatography hplc method was developed for determination of three synthetic endocrine disrupting compoundsedcs, bisphenola bpa, bisphenolaf bpaf and tetrabromobisphenola tbbpa in milk samples.
Determination of melamine in soil samples using surfactant. Dec 05, 2007 the applicability of hollow fiber based liquid phase microextraction hflpme was evaluated for the extraction and preconcentration of three antidepressant drugs amitriptyline, imipramine and sertraline prior to their determination by hplcuv. Liquidphase microextraction combined with hollow fiber as a. Application of hollow fiber liquid phase microextraction. Hollowfiber liquidphase microextraction followed by high. Hollow fiber based liquid phase microextraction combined high. Capillary electrophoresis and hollow fiber liquid phase microextraction for the enantioselective determination of albendazole sulfoxide after biotransformation of albendazole by. A specific, highly enriching and green method for hollow. In this method noctanol was applied as extracting media which was inserted inside lumen of hollow fiber.
The enhancement technique involved dispersing al 2 o 3 particles in n butanol to fill the pores and lumen of a polyether sulfone membrane fiber. Hollowfiber liquidphase microextraction and chiral lcmsms. Hollow fiber liquid phase microextraction hflpme offers an efficient alternative to classical techniques for sample preparation and preconcentration. Lpme method was established for purification and enrichment of glutathione gsh in human saliva followed by a miniaturized capillary electrophoresis with amperometric detection system mini. Hollow fiber supported liquid phase microextraction using ionic liquid as extractant for preconcentration of benzene, toluene, ethylbenzene and xylenes from water sample with gas chromatographyhydrogen flame ionization detection. A new sampling method, termed negligible depletion hollow fiberprotected liquid. Supramolecular nanosolventbased hollow fiber liquid phase. Application of hollow fiber liquid phase microextraction and. The figures of merit in the proposed surfactantenhanced hollow fiber liquid phase microextraction method including dynamic linear range dlr, limit of detection lod based on signaltonoise ratio sn of 3 and relative standard deviation rsd for the extraction of melamine from 5 ml of 3. This study involved the development, validation and application of a three phase hollowfiber liquidphase microextraction hflpme and liquid chromatography with diode array detection lcdad method for the simultaneous determination of the proton pump inhibitor ppi drugs omeprazole, pantoprazole and lansoprazole in human plasma.
A new procedure is presented for the determination of low concentrations of lead and cadmium in water samples. In this study, for the first time, coextraction of acidic, basic and amphiprotic pollutants was performed using supramolecular nanosolventbased hollow fiber liquid phase microextraction sshflpme as an efficient method followed by high performance liquid chromatographyphotodiode array detection. Hollow fiber liquid phase microextraction hflpme and solid phase microextraction spme methods for preconcentration of contaminants toluene, benzophenone, tetracosane and chloroform in food simulants were investigated. Determination of alkylpyrazines in cocoa samples applying. Ligand assisted pseudostir bar hollow fiber solidliquid phase microextraction using solgel sorbent reinforced with carbon nanotubes was combined with differential pulse anodic stripping voltammetry for simultaneous determination of cadmium and lead in tap.
We report the application of the dispersive liquid liquid microextraction coupled to hollow fibre membraneassisted liquid phase microextraction and its application for extraction of atrazine and triclosan. Evaluation of a hollowfiber liquidphase microextraction. Comparison between solid phase microextraction spme and. Analytical and bioanalytical chemistry 2011, 399 6, 20432059. Extraction and determination of three chlorophenols by.
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